Ionically Charged Collagen Sponge

Introduction

The polar sites of collagen are modified using charged ligands under inert atmosphere to prepare ionically charged collagen solution, which is cast into sponge of desired shape and size after incorporating foaming agent, cross linker and drugs. The product has enormous application for treating wounds of ionic nature. Thus it is finds effective use as corneal shield in opthalmological treatment. The porous nature of the product allows faster tissue growth. The soluble collagen solution, obtained as an intermediate, is used in cosmetic and pharmaceutical industries.

Industry classification

Primary : Slaughter house / animal byproducts
Secondary : Drug / pharmaceutical industry

Product type : Commercial

Manufacturing

a) process used
Primary : Biochemical processing
Secondary : Sterilisation and ampouling

b) Major machinery used : Acid and alkali resistant vessel, shakers, homogeniser, Iyophilizer, ethylene oxide chambers, quality control lab, laminar flow chamber, sterilisation chamber.

Status : Yet to be Licensed

Economic Information:

Minimum Economic size: 50 Sponges (10x10 Sq. Cm2) per day
Optimum Investment : Rs.60-80 lakhs

Major Raw Materials Required :

Bovine skin, achilles tendon, proteolytic enzymes, acid, alkali, foaming agent, cross linker, charged (anionic /cationic) ligands, drug, sterilising agent

Patent Information

If Patented : Indian patent applied for
Patent No. : Appl. No.1598DEL99
Country : India
Date granted : Patent Pending

Contact for more information:

Dr. T. Ramasami,
Director, Central Leather Research Institute (CLRI),
Chennai -600 020, India
Tel: +91-(0)44-4910846
Fax: +91-(0)44-4912150
Email: clrimd@md2.vsnl.net.in