Improved
Antimicrobial Nylon Sutures and Products Thereof
Background
Surgical sutures, particularly of non-absorbable type shall
possess good biocompatible and antimicrobial properties. These
are made of either natural or synthetic material. From the
end usage requirement, the base material should have better
strength and elasticity, ease for handling as well as more
affinity to the coating material. Further, the delivery of
antimicrobial agent shall be slow initially and sustained
for longer duration for improving the healing process by eliminating
the danger of infection and inflammation. Since the presently
available sutures does not have all these quality requirements
together, an inherently atimicrobial and biocompatible drug
delivery nylon suture has been developed. These sutures have
wider application also.
Introduction
Saturated solution of poly-N-vinyl-pyrrolidinone-iodine
complex is prepared in a low boiling solvent. Nylon chips
are reacted with this solution for obtaining homogeneous coating
of the solution on the chips. The chips are subsequently dried
and subjected to spinning to draw a filament, preferably a
mano-filament. Drawing multi-filaments is avoided since they
are prone to transmission of bacteria through the hidden areas
in such filaments. To enhance the strength of the filament,
it is drawn at the prescribed temperature with a particular
force. The suture prepared as per the above procedure, have
polar bonding between nylon and poly-N-vinyl-pyrrolidinone-iodine
complex, which results in the slow and controlled release
of iodine from the sutures. Also they have demonstrated inherent
microbial properties in addition to being biocompatible.
Special Features
Inherently antimicrobial and biocompatible
suture which enables to stop the growth of microbes right
at the first step; Release of Iodine is initially slow and
increase sharply and then levels-off for a longer duration,
making the suture suitable for wider application; Does not
cause side effects; Improved strength and elasticity as well
as knot security; Easy handling and cost effective
Prospective Users:
All hospitals and Nursing homes involved in minor and major
surgical operation
Managing Director
Foundation for Innovation and Technology Transfer (FITT)
Indian Institute of Technology, Delhi
Hauz Khas, New Delhi-110016, INDIA
Tel : 91-011-26597167, 26857762, 26581013, 26597153
Fax : 91-011-26851169
E-mail :drkdpn@gmail.com
