Introduction

Indian company offers to provide low cost access to the technologies for the manufacture of high value products along with basic and detailed engineering. In addition to supplying technologies, the company also takes jobs for the toll manufacturing of the intermediates and bulk drugs. It has collaboration with a number of national research laboratories in India for the development of the technologies and continuous strain improvement. The company has worked for a number of projects in India and Europe. It is one of the major consultants in the area of fermentation in India and all the technologies offered are well tried to 90 M3 scale. Recently, it has successfully transferred a fermentation based and a semi-synthetic technology to a reputed pharmaceutical company in Europe and is currently working with a number of reputed companies in Europe. In the project engineering side, the jobs include basic/detailed engineering for the new projects, improvement in existing plant, air pollution control through better scrubbing systems, solvent recovery systems, improvement in existing solvent recovery, etc. The nature of the projects has been quite wide e.g. fermentation projects, intermediates, bulk drugs, pesticides based on natural extracts, colours based on natural extracts, etc. The main technologies offered and indicative technology transfer costs respectively are indicated below:

1. Semi-synthetic penicillins-oral : US$ 100,000 for each of the listed products Amoxycillin Trihydrate Ampicillin Trihydrate Cloxacillin Sodium Flucloxacillin Sodium

2. Cephalosporins-Oral : US$ 100,000 for each of the listed products Cefpodoxime Monohydrate Cefpodoxime Proxetil Cefuroxime Axetil (Amorphous) Cephalexin Monohydrate Cephradine

3. Cephalosporins - Injectables : US$ 100,000 for each of the listed products Cefotaxime sodium sterile Ceftriaxone sodium sterile Ceftazidime

4. Fluoroquinolones : US$ 100,000 for each of the listed products Ciprofloxacin Base Ciprofloxacin Hydrochloride Enrofloxacin Norfloxacin Ofloxacin Trovafloxacin

5. Cardiovasculars: Pavastatin (Fermentation) : US$ 500,000 Compactin (Fermentation) : US$ 500,000 Atorvastatin : US$ 300,000 Lovastatin (Fermentation) : US$ 300,000 Simvastatin : US$ 300,000 Celiprolol : US$ 100,000 Enalpril Maleate : US$ 100,000

6. Anti-Ulcerants: Omeprazole : US$ 100,000

7. Other Products: Rofecoxib : US$ 100,000 Celecoxib : US$ 100,000 Etodolac : US$ 100,000 Fexofenadine : US$ 100,000 Midazolam : US$ 100,000 Pentazocine : US$ 100,000 Sertraline : US$ 100,000 Terfenadine : US$ 100,000 Acyclovir : US$ 100,000 Erythromycin (Fermentation) : US$ 200,000 Rifamycin (Fermentation) : US$ 200,000 Cephalosprin-C (Fermentation) : US$ 200,000 Penicillin-G Acylase (Fermentation) : US$ 200,000 Clarithromycin : US$ 100,000 Fluconazole : US$ 100,000 Phehtolamine : US$ 100,000 Pioglitazone : US$ 100,000

8. Technologies under Development: Benazepril (will be ready in Mar-Apr 2000) : US$ 200,000 Losartan (in May 2000) : US$ 200,000 Orlistat (in 2001) : US$ 600,000 Repaglimide (Mar-Apr 2000) : US$ 100,000 Candesartan (March 2000) : US$ 300,000 The strengths of the company are: Development of fermentation based technologies from wild strains Strain improvement (contract) Development of bulk drug technologies Hands on experience in leading pharmaceutical companies in India and abroad Technology transfer, absorption, scaling up, commercialisation and marketing Engineering, procurement, construction and commissioning of projects Raw material and equipment sourcing Plant automation Statutory approvals (e.g. US FDA, MCA UK, TGA Australia) Eco-friendly technologies as per the requirement Exposure to international manufacturing standards Sourcing of technologies as per requirement

Area of Application: Pharmaceuticals industry, biotechnology: fermentation, semi-synthetic and synthetic drugs

Advantages: Low volume high-value technologies Ecofriendly

Contact:

Asian and Pacific Centre for Transfer of Technology
APCTT Building
C-2 Qutab Institutional Area
P.O.Box - 4575
New Delhi - 110 016
Tel : 91-11-26966509
Fax : 91-11-26856274