Polymer, Plastics and
Rubber Techonologies -
Process for preparation of a novel Hydro gel
Introduction
Hydro gels are cross linked polymeric networks capable
of absorbing large amount of water and drastically increasing
in volume. In general they find application as biomaterial
& super absorbent materials in agro industry and
biomedical engineering. Hydro gel exhibit potential
use as controlled/regulated drug delivery systems, artificial
skin, sutures, membranes for transfusion purposes and
implants. The characteristics of the hydro gel are designed
using appropriate polymers to form Interpenetrating
Polymer Networks (IPN) to achieve the desired physico-chemical
properties. After studying the presently used processes
of producing hydro gels and their limitation, a new
process has been developed to prepare a novel hydro
gel which is pH sensitive, biocompatible, and biodegradable.
The novel Interpenetrating Polymer
Network hydro gels (IPNs) based on FDA approved natural
and synthetic polymers were synthesized and characterized
for biomedical application. The hydro gel can be loaded
with biologically active molecules such as drugs, proteins,
vaccines, antigens, antibiotics, hormones, and pesticides
and other agrochemicals. Percentage of the loading in
the gel varies between 5% to 200% depending on the composition
of the gel. The hydrogel can be molded into desired
shapes such as cylinders, cubes, blocks, sheets etc.
and can be stored in airtight containers at ambient
temperature.
Special Features:
Possess multifarious properties; Releases drug in response
to the external chemical, physical and biological stimuli;
Fully biocompatible and biodegradable resulting into
non-toxic metabolites; Capable of delivering biologically
active molecules such as drugs, proteins, vaccines,
antigens, antibiotics, hormones at specific site and
in a specific manner eliminating the potential of under
and over dosing; Capable of getting loaded with varied
types of biologically, pharmaceutically and therapeutically
active substances; Free of impurities such as monomers,
initiators and other ingredients used in the manufacture
of gel; Maintain effective drug concentration in the
blood over longer periods, maximize efficacy and minimize
side effects; Possess proper geometry and porosity for
desired loading, releasing and degrading capability.
Prospective
Users: As biomaterial
for regulated drug delivery system, sutures, artificial
skin, membranes and super absorbent material in pharmaceutical
industry, agro industry, biomedical engineering.
Developed by
: Prof. (Ms.) Veena Kaul Department: Physics
Contact:
Managing Director
Foundation for Innovation and Technology Transfer (FITT)
Indian Institute of Technology, Delhi
Hauz Khas, New Delhi-110016, INDIA
Tel : 91-011-26597167, 26857762, 26581013, 26597153
Fax : 91-011-26851169
E-mail : drkdpn@gmail.com
