Nano technologies -
Method of Preparation and Composition of Micro and
Nano Devices for Recognition and Signaling
Introduction
The invention combines a novel method
of preparation and a composition consisting of recognitive
polymers with inherent signal transduction. These novel
polymer materials can selectively sense (recognize,
detect, and bind) a previously imprinted protein or
peptide analyte. This property can be extended to other
imprinted molecules, including but not limited to carbohydrates
(mono-, oligo- and polysaccharides), glycoproteins and
proteoglycans, biological and other molecules including
carboxyl, hydroxyl, or amino functional groups, as well
as biologicals containing molecular decoys (moieties)
such as glucose, phenols, polyacids, polyols, polyamines,
polypeptides, etc.
In a further development of this invention,
these copolymer (RECONGEL) materials can be integrated
into intelligent medical or pharmaceutical microdevices
as films on silicon wafers, microcantilevers, glass
slides, polymer films/substrates, and biodegradable
polymer substrates. These RECONGEL systems can also
be used in association with standard photolithography
processes to create novel biosensors with sensing/recognitive
capabilities, as well as associated signal transmitting
capabilities.
IP Status
One U.S. Patent Application Filed.
UT Researcher
Nicholas A. Peppas, Sc.D., Department
of Biomedical Engineering, The University of Texas at
Austin Carolyn L. Bayer, Department of Biomedical Engineering,
The University of Texas at Austin
