Natural and Herbal
Medicine -
Giant Knotweed Extract Resveratrol
Product Class: medicinal
materials
Specifications: 50%,90%,98%.other
Description:
Resveratrol 50%,90%,98% Giant Knotweed
Extract Resveratrol Traditional Andmodernuses: Huzhang
("tiger cane") or giant knotweed is an east
Asian species (Polygonum cuspidatum), belonging to the
Polygonaceae family. Documented uses in traditional
Chinese medicine date to the first century BC, and contemporary
medical uses supported by clinical results include acute
microbial infections or viral hepatitis, chemo- or radiation-induced
leukocytopenia, atherosclerosis, and hyperlipidemia.
Pharmacology: In animal experiments, huzhang has exhibited
antitussive, antihistaminic, hypotensive, vasodilating,
cytotoxic, and antioxidant properties, among others.
Huzhang is also a concentrated source of resveratrol
(3,5,4¡Â-trihydroxy stilbene), an antioxidant
phenol produced in response to fungi. Resveratrol has
also shown antimutagenic activity in bioassays conducted
on bacteria in vitro (umu and Ames tests). And, in a
recent investigation conducted in vivo and in vitro,
resveratrol displayed chemopreventive effects at three
critical stages of carcinogenesis. Specifically, resveratrol
was found to
1) induce phase II drug metabolizing enzymes (antiinitiation);
2) mediate anti-inflammatory effects and inhibit cyclooxygenase
and hydro-peroxidase (antipromotion); and
3) induce human promyelocytic leukemia cell diferentiation
(antiprogression). Resveratrol was also found to inhibit
the development of preneoplastic lesions in vitro and
tumorigenesis in vivo. Very recently, it was reported
that Huzhang extract is one of the best active-oxygen
scavengers for the prevention of skin aging induced
by UV-irradiation and free radical. Experiments conducted
in vivo indicate that resveratrol is a potent vasodilator
and inhibitor of platelet aggregation. Recent work in
dogs and humans indicate that other concentrated sources
of resveratrol (i.e., red wine and grape juice) eliminate
cyclic blood-flow reductions caused by platelet-mediated
thrombosis. Active Compounds: Huzhang is characterized
by anthraquinones and their glycosides, napthoquinone,
3,5,4¡Â-trihydroxy stilbene (i.e., resveratrol),
piceid, fallacinol, citreorosein, questin, questinol,
protocatechuic acid, (+) catechin, 2,5-dimethyl-7- hydroxychromone,
7-hydroxy-4-methoxy-5-methylcoumarin, flavonols, polysaccharides,
and condensed tannins. Regulatory Status: Under U.S.
law, huzhang extract is regulated as a dietary supplement.
As of this writing, no European governments had issued
monographs or regulations for nutraceutical uses of
huzhang. NOTE: The statements in this publication have
not been evaluated by the FDA. Selected Reference: Encyclopedia
of Chinese Drugs. Jiangsu Institute of Modern Medicine,
Shanghai Scientific and Technical Publications, 1977.
[Chinese] Encyclopedia of Common Natural Ingredients
Used in Foods, Drugs, and Cosmetics, by Albert Leung,
Ph.D. and Steven Foster. Hitoshi Masaki et al. Biol
Pharm Bull. 18, 162-166, 1995. Huang WZ. Fujian Zhongyiyao,
18(4), 27, 1987. [Chinese] Kimura Y et al. Planta Med,
48, 164, 1996. Meishang Jang et al. Cancer chemopreventive
activity of resveratrol, a natural product derived from
grapes. Science, vol. 275, 218-220, 1997. Orsini, F.
et al. Isolation, synthesis, and antiplatelet aggregation
activity of resveratrol 3-O-b-D glucopyranoside and
related compounds. J Nat Prod. 60:1082-87, 1997. Pharmacognosy,
Phytochemistry, Medicinal Plants, by Prof. Jean Bruneton.
Lavoisier Tec & Doc/Intercept Ltd., 1995. Records
of Chinese Materia Medica Vol. 1. Institute of Materia
Medica, Chinese Academy of Sciences, 1982. [Chinese]
Contact:
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