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the Fisetin Folium Cotini Extract--Mary Liu is your
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Description:
fisetin Folium Cotini Extract Cotinus
coggygria Scop fisetin Folium Cotini Extract Cotinus
coggygria Scop We have previously shown that, a flavonol,
inhibits IL-4 and IL-13 synthesis by allergen- or anti-IgE-antibody-stimulated
basophils. This time, we investigated the inhibition
of IL-4 and IL-13 production by basophils by other flavonoids
and attempted to determine the fundamental structure
of flavonoids related to inhibition. We additionally
investigated whether flavonoids suppress leukotriene
C4 synthesis by basophils and IL-4 synthesis by T cells
in response to anti-CD3 antibody. Methods: Highly purified
peripheral basophils were stimulated for 12 h with anti-IgE
antibody alone or anti-IgE antibody plus IL-3 in the
presence of various concentrations of 18 different kinds
of flavones and flavonols. IL-4 and IL-13 concentrations
in the supernatants were then measured. Leukotriene
C4 synthesis was also measured after basophils were
stimulated for 1 h in the presence of flavonoids. Regarding
the inhibitory activity of flavonoids on IL-4 synthesis
by T cells, peripheral blood mononuclear cells were
cultured with flavonoids in anti-CD3-antibody-bound
plates for 2 days.
Results: Luteolin, fisetin and apigenin were found to
be the strongest inhibitors of both IL-4 and IL-13 production
by basophils but did not affect leukotriene C4 synthesis.
At higher concentrations, these flavonoids suppressed
IL-4 production by T cells. Based on a hierarchy of
inhibitory activity, the basic structure for IL-4 inhibition
by basophils was determined. Conclusions: Due to the
inhibitory activity of flavonoids on IL-4 and IL-13
synthesis, it can be expected that the intake of flavonoids,
depending on the quantity and quality, may ameliorate
allergic symptoms or prevent the onset of allergic diseases
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