Medicinal Technologies-
Improved Antimicrobial Nylon Sutures and Products
Thereof
Introduction
Surgical sutures, particularly of
non-absorbable type shall possess good biocompatible
and antimicrobial properties. These are made of either
natural or synthetic material. From the end usage requirement,
the base material should have better strength and elasticity,
ease for handling as well as more affinity to the coating
material. Further, the delivery of antimicrobial agent
shall be slow initially and sustained for longer duration
for improving the healing process by eliminating the
danger of infection and inflammation. Since the presently
available sutures does not have all these quality requirements
together, an inherently atimicrobial and biocompatible
drug delivery nylon suture has been developed. These
sutures have wider application also.
Description:
Saturated solution of poly-N-vinyl-pyrrolidinone-iodine
complex is prepared in a low boiling solvent. Nylon
chips are reacted with this solution for obtaining homogeneous
coating of the solution on the chips. The chips are
subsequently dried and subjected to spinning to draw
a filament, preferably a mano-filament. Drawing multi-filaments
is avoided since they are prone to transmission of bacteria
through the hidden areas in such filaments. To enhance
the strength of the filament, it is drawn at the prescribed
temperature with a particular force. The suture prepared
as per the above procedure, have polar bonding between
nylon and poly-N-vinyl-pyrrolidinone-iodine complex,
which results in the slow and controlled release of
iodine from the sutures. Also they have demonstrated
inherent microbial properties in addition to being biocompatible.
Special Features:
Inherently antimicrobial and biocompatible
suture which enables to stop the growth of microbes
right at the first step; Release of Iodine is initially
slow and increase sharply and then levels-off for a
longer duration, making the suture suitable for wider
application; Does not cause side effects; Improved strength
and elasticity as well as knot security; Easy handling
and cost effective
Prospective
Users: All hospitals and Nursing homes involved
in minor and major surgical operation
Indian Patent Application No. 3032/DEL/98
dated 13.10.1999 having title ' A Method for preparation
of Improved Antimicrobial Nylon Sutures and Products
thereof'
Status of Development:
The technology has been developed
with the facilities available in IIT, Delhi on batch
and continuous operations.
Major Equipment
& Facilities required: Extruder, Drawing
unit, Reaction vessels, drier, etc. at a total estimated
cost of 15 lakhs. appr
Requirement of Raw Materials/Components:
Polypropylene
Poly-N-vinyl-pyrrolidinone-iodine
Acetone
Developed by : Prof. Harpal Singh
Department: Center for Biomedical Engineering
Contact:
Managing Director
Foundation for Innovation and Technology Transfer (FITT)
Indian Institute of Technology, Delhi
Hauz Khas, New Delhi-110016, INDIA
Tel : 91-011-26597167, 26857762, 26581013, 26597153
Fax : 91-011-26851169
E-mail : drkdpn@gmail.com
