Medicinal Technologies-
Negatively Charged Prostheses and Products
Introduction
Coronary angioplasty, the technique
of opening of chocked arteries of the heart , is the
most important therapeutic procedure for avoiding open
heart surgery. The major drawback of this technique
is the propensity of the dilated artery to close abruptly
and also the tendency for the recurrence of obstruction.
Though, intravascular metallic stents are implanted
for overcoming these drawbacks, acute thrombosis has
not been totally eliminated. Further, due to initiation
of complex interaction between blood components and
the metallic surface of the implanted stent, the chances
of thrombosis increase because of deposition of proteins
and other blood cells on the stent surface. Presently
used methods such as polymer coating, incorporation
of thrombogenic drugs or substance in polymer coating
of the stent do not eliminate the said complex interaction
completely. From this point of view, a new method of
preparing the prosthesis i.e. metallic stent has been
developed as described below.
Description:
The method comprises two steps, wherein
the first step involves coating of the prosthesis and
the second step involves charging i.e. negative charging
of the coated prosthesis. In the first step the coating
material, preferably a low density material is dissolved
in an aromatic solvent at a specified temperature for
preparing the coating solution. The solution is maintained
at this temperature and the prosthesis is coated by
dipping into this solution in hot condition for a specific
period. The coated prosthesis is subsequently taken
out, heated at a higher temperature than that of the
solution and tested for coating characteristics such
as uniformity, thickness, etc. During the second step,
the coated prosthesis is placed on a metal platform
and exposed to the beam of electron, the negatively
charged beam generated under a positive potential of
1.5 to 2.5 kV, preferably under a scroton unit. The
prosthesis is continuously rotated to have uniform charging.
Negative charge gets deposited on to the coated prosthesis
which can be assessed by any known method.
Special Features:
Enables effective implantation of
metallic stents in the coronary angioplasty procedure
Complex reactions between blood components and the metallic
surface leading to increased chances of thrombosis is
taken care of , A simple and easy method of coating
is adopted.
Prospective
Users: Major hospitals and Nursing homes involved
in the operation of heart
Keywords:
Coronary angioplasty, coating, electron beam, negative
charge
Status of IPR
Protection: Indian Patent Application No. 750/DEL/99
dt. 18.5.1999
Developed by : Dr. K V Tripathi
Department: Physics
Contact:
Managing Director
Foundation for Innovation and Technology Transfer (FITT)
Indian Institute of Technology, Delhi
Hauz Khas, New Delhi-110016, INDIA
Tel : 91-011-26597167, 26857762, 26581013, 26597153
Fax : 91-011-26851169
E-mail : drkdpn@gmail.com
