Medicinal Technologies-
Process for Preparation of a Novel Hydro Gel
Introduction
Hydro gels are cross linked polymeric
networks capable of absorbing large amount of water
and drastically increasing in volume. In general they
find application as biomaterial & super absorbent
materials in agro industry and biomedical engineering.
Hydro gel exhibit potential use as controlled/regulated
drug delivery systems, artificial skin, sutures, membranes
for transfusion purposes and implants. The characteristics
of the hydro gel are designed using appropriate polymers
to form Interpenetrating Polymer Networks (IPN) to achieve
the desired physico-chemical properties. After studying
the presently used processes of producing hydro gels
and their limitation, a new process has been developed
to prepare a novel hydro gel which is pH sensitive,
biocompatible, and biodegradable.
Description:
The novel Interpenetrating Polymer
Network hydro gels (IPNs) based on FDA approved natural
and synthetic polymers were synthesized and characterized
for biomedical application. The hydro gel can be loaded
with biologically active molecules such as drugs, proteins,
vaccines, antigens, antibiotics, hormones, and pesticides
and other agrochemicals. Percentage of the loading in
the gel varies between 5% to 200% depending on the composition
of the gel. The hydrogel can be molded into desired
shapes such as cylinders, cubes, blocks, sheets etc.
and can be stored in airtight containers at ambient
temperature.
Special Features:
Possess multifarious properties; Releases
drug in response to the external chemical, physical
and biological stimuli; Fully biocompatible and biodegradable
resulting into non-toxic metabolites; Capable of delivering
biologically active molecules such as drugs, proteins,
vaccines, antigens, antibiotics, hormones at specific
site and in a specific manner eliminating the potential
of under and over dosing; Capable of getting loaded
with varied types of biologically, pharmaceutically
and therapeutically active substances; Free of impurities
such as monomers, initiators and other ingredients used
in the manufacture of gel; Maintain effective drug concentration
in the blood over longer periods, maximize efficacy
and minimize side effects; Possess proper geometry and
porosity for desired loading, releasing and degrading
capability.
Prospective Users:
As biomaterial for regulated drug
delivery system, sutures, artificial skin, membranes
and super absorbent material in pharmaceutical industry,
agro industry, biomedical engineering.
Indian Patent Application no: 1068/DEL/2002
dated 24th October 2002 with the title "A Process
for preparation of Hydro gel"
Status of Development: Product
is ready for First phase clinical trail
Requirement of Raw Materials/Components:
Differential Scanning Calorimeter
(DSC)
Thermal Gravimatetric Analyzer
FT-IR
Developed by : Prof. (Ms.) Veena Kaul
Department: Physics
Contact:
Managing Director
Foundation for Innovation and Technology Transfer (FITT)
Indian Institute of Technology, Delhi
Hauz Khas, New Delhi-110016, INDIA
Tel : 91-011-26597167, 26857762, 26581013, 26597153
Fax : 91-011-26851169
E-mail : drkdpn@gmail.com
